What is/are Lotrel?

AMLODIPINE-BENAZEPRIL is a combination of two drugs. It is used to treat high blood pressure. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care providers before I take this medicine?

They need to know if you have any of these conditions:

• bone marrow disease
• heart or blood vessel disease
• if you are on a special diet, such as a low-salt diet
• immune system disease or disorder, like lupus
• kidney or liver disease
• previous swelling of the tongue, face, or lips with difficulty breathing, difficulty swallowing, hoarseness, or tightening of the throat
• an unusual or allergic reaction to amlodipine, benazepril, other medicines, insect venom, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. You can take the capsules with or without food. Do not significantly increase grapefruit juice intake while taking this drug, or avoid grapefruit juice if possible. Take your doses at regular intervals. Do not take your medicine more often then directed. Do not stop taking except on the advice of your doctor or health care professional.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

Note: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep this medicine?

Keep out of the reach of children.

What may interact with this medicine?

• diuretics, especially amiloride, triamterene, or spironolactone
• lithium
• medicines for blood pressure
• potassium salts or potassium supplements

This list may not describe all possible interactions. Give your health care providers a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. Check your blood pressure as directed. Ask your doctor or health care professional what your blood pressure should be and when you should contact him or her. Call your doctor or health care professional if you notice an irregular or fast heart beat.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this drug affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol can make you more drowsy and dizzy. Avoid alcoholic drinks.

If you are going to have surgery, tell your doctor or health care professional that you are taking this medicine.

Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information.

Check with your doctor or health care professional if you get an attack of severe diarrhea, nausea and vomiting, or if you sweat a lot. The loss of body fluid can make it dangerous to take this medicine.

A few patients have had strong allergic reactions during desensitization treatment with hymenoptera venom and during some kinds of dialysis. Talk to your doctor if you are going to have either of these procedures.

Avoid salt substitutes unless you are told otherwise by your doctor or health care professional.

Do not treat yourself for coughs, colds, or pain while you are taking this medicine without asking your doctor or health care professional for advice. Some ingredients may increase your blood pressure.

What side effects may I notice from this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

• allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
• breathing problems
• chest pain
• dry cough
• fast, irregular heartbeat
• redness, blistering, peeling or loosening of the skin, including inside the mouth
• stomach pain
• swelling of your ankles, legs
• trouble passing urine or change in the amount of urine

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

• drowsiness or dizziness
• facial flushing
• headache

This list may not describe all possible side effects.